If you frequently use Facebook and Twitter you may find yourself toggling between both applications frequently on your desktop.
Fortunately a new application SEESMIC can help DE-clutter your desktop. If you have used "TweetDeck" this program is very similar and can do much more. The first thing you will notice is that the interface is more "Twitter-like" than the interface of Tweetdeck. Seesmic will allow you to update your Facebook and Twitter status. You can create particular groups of people and also track particular hashtag items for specific searches. All of this activity is now conveniently all on one window. The cool thing I like about this application is that you can maintain multiple accounts.
This application is still in Beta but can be downloaded for free at their site mentioned above. Here is a short clip and explanation of the new Seesmic Desktop.